Computer Aided Drug Design

Katsimula

Computer aided drug design (CADD) is an efficient tool in the search for promising drug candidates, especially when used with existing chemical biology screening techniques. CADD techniques by the best pharmaceutical companies and other research groups needed to accelerate the drug development process more cost-effectively for the preliminary stage of the drug discovery process and to minimize the errors in the final stage.

Our team focused on computer-aided drug design (structure based: Docking, Ligand based: pharmacophore, QSAR)) and computational protein structure modelling (homology modelling, MD simulation) techniques in their research studies to reduce the experimental burden and the wet laboratory studies in terms of time and cost. They have several national and international projects related to these fields. .

Detailed Information

PROJECT TEAM

Person

Dr. Ercüment YILMAZ

Principal Investigator

Graduated from Karadeniz Technical University, Department of Statistics and Computer Science. Earned his master's and doctorate degrees from Karadeniz Technical University Department of Computer Engineering. He completed his post-doctoral studies at ISEP institute in Paris. He works as senior lecturer at Karadeniz Technical University, Department of Computer Technologies. He is also the founder and company director of Yılmaz Bilişim R&D.

Person

Assoc. Prof.Dr. Gizem TATAR YILMAZ

Co-Principal Investigator

Graduated from Haliç University, Department of Molecular Biology and Genetics. Completed her master's degree in Kadir Has University, Department of Computational Biology and Bioinformatics and PhD in Gaziantep University, Department of Bioinformatics and Computational Biology. She is a faculty member at Karadeniz Technical University, Faculty of Medicine, Biostatistics and Medical Informatics Dept.

Person

Assoc. Prof. Dr. Fatih KOCABAŞ

Drug Development & R&D

He is a graduate of Middle East Technical University, Department of Molecular Biology and Genetics. He completed his PhD in Genetics program at University of Texas Southwestern Medical Center Dallas. He is a faculty member at Yeditepe University, Department of Genetics and Bioengineering. He is also the founder of Meinox Pharma Technologies.


Person

Dr. Cihan İNAN

BIOINFORMATICS  & R&D

He is a graduate of Karadeniz Technical University, Biology Teaching. He completed his master's degree in Molecular Biology and Genetics at Istanbul University. He received his Ph.D. from Karadeniz Technical University, Department of Biology. He is a faculty member at Karadeniz Technical University, Department of Molecular Biology and Genetics.

SELECTED PUBLICATIONS

1. Mermer Arif, Demirci Serpil, Tatar Yilmaz Gizem (2022). "Synthesis of novel pancreatic lipase inhibitors: Biological investigation and in silico studies.", Journal Of Biomolecular Structure And Dynamics, 40(2), 931-940., Doi: 10.1080/07391102.2021.1950573

2. Tatar Gizem, Ozyurt Ezgi, Turhan Kemal (2021). "Computational drug repurposing study of the RNA binding domain of SARS-CoV-2 nucleocapsid protein with antiviral agents.", Biotechnology Progress, 37(2), Doi: 10.1002/btpr.3110

3. Salmanlı Merve, Tatar Yılmaz Gızem, Tüzüner Tamer (2021). "Investigation Of The Antimicrobial Activities Of Various Antimicrobial Agents On Streptococcus Mutans Sortase A Through Computer-Aided Drug Design (CADD) Approaches.", Computer Methods and Programs In Biomedicine, 212, Doi: 10.1016/J.Cmpb.2021.106454

4. Tatar Gizem, Salmanli Merve, Dogru Yakup, Tüzüner Tamer (2021). "Evaluation of the effects of chlorhexidine and several flavonoids as antiviral purposes on SARS-CoV-2 main protease: molecular docking, molecular dynamics simulation studies.", Journal of Biomolecular Structure and Dynamics, Doi: 10.1080/07391102.2021.1900919

5. Tatar Yılmaz Gızem, Yılmaz Ercüment (2021). "Evaluation of Antiviral Compounds Against SARS-CoV-2 Main Protease Enzyme by Computer Aided Drug Design Methods.", European Journal of Science and Technology, 32, 1043-1047, Doi:10.31590/ejosat.1041077

Motor Vehicle Fault Detection System



Katsimula

MATS

The main purpose of this project is to provide a decision support system to both vehicle users and employees in vehicle repair services for the detection of motor vehicle malfunctions. In the project, malfunctions in automobiles are detected by analyzing the sounds emitted from the vehicle by pattern recognition and machine learning methods.

In the project, it is aimed that the mechanical failures in the motion propulsion systems (engine systems) used in motor vehicles can be easily detected by the user with the MATS software developed within the scope of the project. Thus, without wasting time and without the need for advanced expertise, the causes of malfunctions of motor vehicles will be presented to the interested parties and early fault detection will be possible without major damage.

PROJECT TEAM

Person

Dr. Ercüment YILMAZ

Principal Investigator

Graduated from Karadeniz Technical University, Department of Statistics and Computer Science. Earned his master's and doctorate degrees from Karadeniz Technical University Department of Computer Engineering. He completed his post-doctoral studies at ISEP institute in Paris. He works as senior lecturer at Karadeniz Technical University, Department of Computer Technologies. He is also the founder and company director of Yılmaz Bilişim R&D.

Person

Assoc. Prof. Dr. Önder AYDEMİR 

Researcher & R&D

Graduated from Karadeniz Technical University, Department of Electrical and Electronics Engineering. Earned his master's and doctorate degrees from Karadeniz Technical University Department of Electrical-Electronics Engineering .   He completed his post-doctoral studies at Medizinische Universitaet Wien in Vienna. He is a faculty member at the Department of Electrical and Electronics Engineering at Karadeniz Technical University.

Person

Dr. Sinan KÖSE 

Researcher & R&D

Graduated from Karadeniz Technical University Mechanical Engineering Department and Fisheries Technology Engineering Department . He earned his master's degree from Karadeniz Technical University Department of Mechanical Engineering . He received his doctorate degree from Karadeniz Technical University Department of Mechanical Engineering . He is a faculty member at Tarsus University, Department of Machinery and Metal Technologies.

Person

Lect. Seda AKYAZ ALAÇAM 

Researcher & R&D

Graduated from Sakarya University Automotive Teaching. Earned her master's degree from Karadeniz Technical University Department of Mechanical Engineering. She works as a lecturer at Karadeniz Technical University, Department of Machinery and Metal Technologies.

SELECTED PUBLICATIONS

1. Yilmaz Goktug, Mete Necip Fazil, Umusalama Umugabekazi, Aydemir Onder (2020). "Wavelet Transform and Autoregressive Model Parameter Features based Engine Fault Diagnosis System.", Journal of Investigations on Engineering & Technology, 3(2), 48-54., Retrieved from https://dergipark.org.tr/en/pub/jiet/issue/58854/826981

HIGHWAY TRAFFIC SIMULATION

This project was supported by Tübitak 1512 program in 2014.



Katsimula

KATSIMULA

In the ongoing study, it is aimed to produce software that will simulate a traffic network with different parameters, and to determine the most appropriate traffic engineering solution by comparing the results obtained through this software.

In software, a traffic network can be designed in computer environment in accordance with Traffic Engineering rules. . The visual, statistical data and reports to be produced through the software will provide the opportunity to create a less costly and better functioning traffic system in real life.

Detailed Information

PROJECT TEAM

Person

Dr. Ercüment YILMAZ

Principal Investigator

Graduated from Karadeniz Technical University, Department of Statistics and Computer Science. Earned his master's and doctorate degrees from Karadeniz Technical University Department of Computer Engineering. He completed his post-doctoral studies at ISEP institute in Paris. He works as senior lecturer at Karadeniz Technical University, Department of Computer Technologies. He is also the founder and company director of Yılmaz Bilişim R&D.

Person

Dr. Tolga BERBER

software developer  & R&D

Graduated from Karadeniz Technical University, Department of Statistics and Computer Science. He completed his master's and doctoral studies at Dokuz Eylul University Department of  Computer Engineering . He is a faculty member at the Department of Statistics and Computer Sciences at Karadeniz Technical University.



Person

Dr. Uğur ŞEVİK

SOFTWARE DEVELOPER & R&D

Graduated from Karadeniz Technical University, Department of Statistics and Computer Science. He completed his master's and doctoral studies at Karadeniz Technical University Department of Computer Engineering. He is a faculty member at the Department of Statistics and Computer Sciences at Karadeniz Technical University. He is also the founder and company director of Retina R&D Software company.

Person

Prof.Dr. Cemal KÖSE

PROJECT ADVISOR 

Graduated from Karadeniz Technical University, Electrical and Electronics Engineering. He completed his master's degree in DEpartment of Electronics Engineering at Karadeniz Technical University. He earned his PhD in Department of Computer Science from the University of Bristol. He is a faculty member at Karadeniz Technical University Computer Engineering Department.

Person

Dr. Ebru Arıkan ÖZTÜRK

PROJECT ADVISOR

Graduated from Gazi University, Department of Civil Engineering. Completed her master's degree in Gazi University Department of Traffic Planning and Application. She received her PhD from Gazi University, Environmental and Technical Research on Accidents, USA. He is a faculty member at Gazi University, Institute of Science and Technology, Traffic Planning and Application USA.

Person

Prof.Dr. Doğan GÜVEN

PROJECT BUSINESS CONSULTANT

Graduated from Hacettepe University Computer Engineering Department. He completed his master's and doctorate studies at Ege University Computer Engineering Department. He is Director of Doctorate Programs & Department Head of Computer Science and Business Analytics Programs at the International University of Geneva.

SELECTED PUBLICATIONS

1. Yılmaz, Ercüment. "Karayolu Trafik Simülasyonu". Diss. Karadeniz Teknik Üniversitesi, 2006., Retrieved from https://tez.yok.gov.tr/UlusalTezMerkezi

servıces

Our company offers the services stated in the following titles

Software Development

Our company offers special solutions for individuals and institutions in its main field of software development services.

Project Proposal Management

R&D-oriented project design, creation of project business plans, government and/or private institution-supported project applications.

Consultancy

Our company offers all kinds of consultancy services for individuals and institutions related to the subjects within its main fields of activity.

Education

Special training services are offered to individuals and institutions in areas such as software development, project risk management, entrepreneurship, company establishment, etc.

R&D

Services are provided for individuals and organizations for R&D support in the fields of software development and project management.

Engineering Services

Services related to the installation of special purpose software, electronic systems and hardware products and the provision of technical support for these products.


achıevements

We became the Semi-Finalist and Category 9th in Turkey in the 2015 Inovalig competition.

In 2014 and 2015, we participated in the InovaLIG innovation competition, which was held for the first time in Turkey with the partnership of the Turkish Exporters Assembly and ATKearney. We competed in 5 different categories with 460 companies in 2014 and 488 companies in 2015 in the organization attended by well-established and powerful companies operating in different sectors. In the semi-finals, we competed against well-established and powerful companies in different sectors. We hosted the Turkish Exporters Assembly and ATKearney officials in our company and gave information about our innovation strategies. At the award ceremonies held within the scope of the Innovation Week, we achieved the 10th place in 2014 and 9th place in 2015 in the category of  "Innovation Sources", and we completed the competition by being among the top 10 companies in Turkey one after the other.

Detailed Information : http://www.inovalig.com



INOVALIG 2015

PRESS RELEASES

Interviews about   Yılmaz Bilişim and  "Traffic Simulation Software" product took place in the national and local press.

Traffic Simulation Software News
(TRT HABER)

The news about our Traffic Simulation Software project on TRT Haber national TV channel was broadcast on 17.05.2016 at 17:00.

NEWS VIDEO

Traffic Simulation Software News
(A Haber)

The news about the Traffic Simulation Software project was broadcast in the Night Agency and Morning Agency news programs on A News channel on 15.03.2016.

NEWS VIDEO

Working for the Correct Planning of the Traffic Network (Hürriyet)

Domestic traffic simulation software was produced within the scope of the project prepared by Yılmaz Bilişim company within Teknokent in Trabzon.

INTERVIEW

 

Innovation Award with Traffic Simulation Software (Milliyet)

Ercüment Yılmaz, who carries out his activities within Teknokent, came 9th in the category of innovation resources in the İnovaLİG competition.


INTERVIEW

Teknokentler
Yılmaz Bilişim
(ICT Media)

Yılmaz Bilişim was introduced in the June 2015 issue of IctMedia Information and Communication Technologies Magazine, and the Traffic Simulation Software project was covered in detail.

Full Text